First, you must create email accounts in the control panel.
Once created, open the Windows Mail program and follow these steps to configure it:
From the menu, select Tools and then Accounts...
In the window that appears, select Add to add the email account.
Select Email Account and click Next.
Enter the name you want the recipient to see when you send an email.
Once completed, select Continue to proceed.
Enter the email account you want to configure.
Configure the incoming and outgoing mail server in POP3 as follows.
Incoming mail server (POP3 or IMAP): mail.mydomain.com.
Outgoing mail server name (SMTP): mail.mydomain.com
Select the "My outgoing server requires authentication" checkbox.
Fill out the following form indicating the email account you are configuring as well as its password.
With this, the email account is configured in Windows Mail for Windows Vista.